With rain coming down all Friday morning, and a mix of snow and rain in Minneapolis' forecast for the evening, the official decision was reached at approximately 2 p.m. ET.
Friday's scheduled Orioles starter Kevin Millwood and fellow right-hander Jeremy Guthrie will pitch Saturday, though the team has not yet determined in which order they'll start. The Twins were slated to send lefty Francisco Liriano to the hill Friday, and it wasn't immediately known if Minnesota would stick with their original rotation order.
While both the Orioles and the Twins have an offday Monday, the two clubs elected to keep that day free and play a twinbill Saturday instead. The early forecast for Saturday, according to AccuWeather.com, is partly sunny and temperatures in the low 50s.
The Orioles won Thursday's opener of the four-game set, 2-0. Friday's rainout was Baltimore's first this season.
Brittany Ghiroli is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.