O's manager Buck Showalter came out to challenge the call, claiming Encarnacion's foot came off the bag. But the call stood after a replay review.
The Orioles are now 5-for-10 in replay reviews this season.
Brittany Ghiroli is a reporter for MLB.com. Read her blog, Britt's Bird Watch, and follow her on Twitter @britt_ghiroli. This story was not subject to the approval of Major League Baseball or its clubs.