He's scheduled to make his final start of the spring on short rest on Saturday against the Red Sox, and Pelfrey is expected to throw about 90 pitches in that outing. He was also originally slated to pitch in a Minor League game with Triple-A Rochester on Tuesday but pitched in the Grapefruit League game because the Minor League field was in bad condition due to the rain on Monday.
"I felt fine," Pelfrey said. "My command in the first inning wasn't good. I went 3-2 on all three hitters. Not a lot of guys have 1-2-3 first innings with 25 pitches. But I plan to get better."
Right-hander Bud Norris started for the Orioles and went 5 1/3 innings, giving up three runs (two earned) on seven hits and a walk with two strikeouts.
"I'm excited. I think we all are," said Norris, who will pitch either the fourth or fifth game of the season. "We've been champing at the bit. We've been working hard. Like I said, for us to get out of here healthy is the No. 1 priority. I'm excited to get this going."
The Twins scored twice in the second, as Josh Willingham reached on an error by shortstop Alexi Casilla and came around to score on a double by Plouffe. Plouffe promptly scored on a single by Oswaldo Arcia.
Minnesota scored again in the fifth, when Brian Dozier hit a single and stole second base before scoring on a single by Mauer. Minnesota added an insurance run in the seventh on a two-out RBI double by Chris Colabello off Tommy Hunter.
Left-hander Scott Diamond pitched the middle three innings for the Twins, surrendering one run on two hits with a strikeout.
The Orioles scored against Diamond in the fifth on a sacrifice fly by Steve Pearce to plate Steve Clevenger, who led off the inning with a single.
Right-hander Kyle Gibson, who was originally scheduled to make the start against the Orioles, pitched the final three innings for the Twins. Gibson is the front-runner to be the club's fifth starter over Diamond, and he threw three scoreless innings.
Up next: The O's will play a pair of games on Wednesday, starting with a 1:05 p.m. ET game in Fort Myers against the Red Sox. That game will be started by Miguel Gonzalez. Opening Day starter Chris Tillman will pitch the nightcap in Port Charlotte at 7:05 p.m. against Rays lefty David Price (watch on MLB.TV).
Rhett Bollinger is a reporter for MLB.com. Read his blog, Bollinger Beat, and follow him on Twitter @RhettBollinger. This story was not subject to the approval of Major League Baseball or its clubs.