The Twins scored their lone run against Chen in the second, when Eduardo Escobar laced an RBI single to score Chris Parmelee, who drew a two-out walk and reached second on an infield single from Darin Mastroianni.
"Except for the walk I issued in the second inning, I was overall pretty pleased with my start," Chen said. "But I didn't have good command on that at-bat. I was upset about that. But except for that, I was pretty pleased."
Right-hander Mike Pelfrey made his fourth start of the spring for the Twins, surrendering one run on five hits and a walk with two strikeouts over 3 1/3 innings.
"I felt like I was OK," Pelfrey said. "I thought the fastball command was good and the split was good but the slider wasn't very good at all. But I thought I was better than last time out and went a little deeper, too."
Pelfrey gave up a run in the second on a sacrifice fly from Quintin Berry after loading the bases with nobody out. But Pelfrey was able to work out of the jam after the sac fly, getting Michael Almanzar to ground into a fielder's choice and striking out Xavier Paul to end the inning.
Pelfrey ran into another jam in the fourth, as he gave up a one-out double to Jonathan Schoop and was removed from the game in favor of left-hander Brian Duensing. Duensing was able to strand both inherited runners by striking out Berry and getting Almanzar to ground out to third.
Duensing, though, gave up a go-ahead homer to Henry Urrutia with two outs in the fifth. It was the first homer of the spring for Urrutia and the third given up by Duensing.
Up next: Suk-min Yoon will make his debut on Saturday for the Orioles, who will host the Yankees at 1:05 p.m. ET (MLB.TV, Gameday Audio) at Ed Smith Stadium. Chris Tillman will start the game with Evan Meek, Darren O'Day and Zach Britton also scheduled to pitch.
Rhett Bollinger is a reporter for MLB.com. Read his blog, Bollinger Beat, and follow him on Twitter @RhettBollinger. This story was not subject to the approval of Major League Baseball or its clubs.