"It looked like he walked off the field fine," bench coach John Russell said. "So I would say that he's going to be all right."
Gonzalez was scheduled to start Thursday's game against the Rays before it was canceled due to rain, forcing him to appear in Friday's contest after starter Ubaldo Jimenez and left-hander Brian Matusz.
Gonzalez entered the game in the top of the fifth inning, induced a groundout from Kevin Frandsen and gave up a double to Cody Asche, then Rupp smoked a pitch right back at the mound.
The ball ricocheted off Gonzalez's lower leg, sending him to the ground. He stood up on his own power before walking off the field and into the Orioles' clubhouse with head athletic trainer Richie Bancells.
Adam Berry is a reporter for MLB.com. Follow him on Twitter at @adamdberry. This story was not subject to the approval of Major League Baseball or its clubs.