Five innings and 81 pitches later, Uehara's first outing since suffering a left hamstring injury on May 23 was over.
He'll make his second start since returning from the disabled list Wednesday night against the New York Mets.
In his first start off the DL, Uehara allowed four earned runs on seven hits, striking out three and issuing just one walk.
But that was against a Seattle Mariners team that was 11th in the American League in team hitting, batting a collective .257. The Mets enter Wednesday's game second in the National League and third in the Major Leagues batting .278.
Leading the attack against Uehara will be the Mets' duo of Carlos Beltran and David Wright. Beltran is second in the NL with a .344 batting average, trailing only Wright, who his hitting .364. Right-handed batters are hitting .308 against Uehara this season.
Uehara was placed on the 15-day disabled list on May 27 with a left hamstring injury. He admitted that his hamstring has been an issue for a substantial part of his career, but it is something he has tried to cope with.
Uehara is just 2-4 this season and hasn't won a start since an April 13 start against Texas.Pitching matchup
BAL: RHP Koji Uehara (2-4, 4.37 ERA)
Uehara was sharp through the first two innings against the Mariners on Wednesday, issuing only one walk and striking out two. The third inning began after a nearly 30-minute rain delay, upon which the Mariners scored three runs. NYM: RHP Tim Redding (0-2, 6.18 ERA)
He doesn't have a win to show for it, but things have been getting better for Redding, who had poor outings in his second and third starts after returning from the DL. He held the Nationals to one run in six innings on June 5 and the Phillies to three runs in seven innings his last time out Thursday. He has walked only two batters in his past 13 innings after walking 10 in his first 14 2/3 Tidbits
In Uehara's past 10 starts, the Orioles are just 3-7, including a 1-4 record at home. ... Nick Markakis leads the AL with seven outfield assists. Teammate Adam Jones is tied for fourth with five. ... Before the series with the Mets, the Orioles were 4-2 against the NL East. ... Baltimore is 3-7 on Wednesday games, but all three wins have come at home. ... The Orioles promoted left-handed pitcher Brian Matusz, the fourth overall pick in the 2008 First-Year Player Draft, from Class A Frederick to Double-A Bowie. Matusz went 4-2 with a 2.16 ERA in 11 starts with Frederick. Tickets
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Thursday: Orioles (Jason Berken, 1-3, 7.32) vs. Mets (Livan Hernandez, 5-1, 4.33), 7:05 p.m. ET
Friday: Orioles (Rich Hill, 2-1, 5.81) at Phillies (Antonio Bastardo, 2-1, 5.25), 7:05 p.m. ET
Saturday: Orioles (Brad Bergesen, 4-2, 3.79) at Phillies (J.A. Happ, 4-0, 3.53), 7:05 p.m. ET
Brian Eller is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.