Gonzalez will follow rookie Wei-Yin Chen, who took the mound on Monday night with six days' rest. The club has also taken great care in preserving Gonzalez, who was signed out of the Mexican Winter Leagues and started the season as a reliever.
The right-hander, who had just one career start above Double-A, has been one of the best stories this season, and the Orioles have closely monitored his innings down the stretch. Gonzalez has pitched to a 4.55 ERA in nine starts on regular rest, a mark that drops to 2.52 when getting six or more days of rest.
First pitch on Wednesday is scheduled for 7:30 p.m. ET on TBS.
Gonzalez last pitched Tuesday against the Rays, throwing 6 1/3 scoreless innings at Tropicana Field. He has excelled on the road and is 2-0 with a 2.63 ERA in two career starts at Yankee Stadium.
How has he been able to be so successful?
"First off, it's location," catcher Matt Wieters said of Gonzalez, who has a 3.25 ERA in 18 games (15 starts). "He can locate his fastball, which is going to give any pitcher a good chance to succeed, and he's been able to improve his offspeed as the year has gone on and really feel like he has four pitches that he can throw at any time and in any count."