Lester, who is 14-0 in 18 regular-season starts vs. the Orioles, allowed one hit and notched two strikeouts, but he also issued four walks. The southpaw retired seven of the last eight batters he faced to end his first Grapefruit League start on a high note.
Journeyman Dana Eveland struggled for the Orioles, allowing three runs (one earned) and only went two innings instead of the originally scheduled three. Eveland, who consistently fell behind most of the Red Sox's lineup, didn't do much to help his case in the team's starter/bullpen competition, and he was followed by a perfect inning from lefty Zach Phillips.
"I threw way too many pitches and gave up too many hits," said Eveland. "I felt pretty good, but obviously against this lineup, you can't really make too many mistakes, and I paid for pretty much every mistake I did make today. That's the difference between having a good outing and a bad one. They hit every mistake I made."
Red Sox second baseman Dustin Pedroia went 2-for-3 with a pair of RBIs, while Cody Ross had a pair of hits and two runs scored.
O's right-hander Chris Tillman allowed just one hit over three scoreless innings, while Luis Ayala allowed a run in the seventh after issuing a pair of back-to-back walks.
"He's getting strong enough to have a better delivery," pitching coach Rick Adair said of Tillman, who hit 95 mph on Sunday. "When guys are much stronger, it's a huge deal."
Adam Jones put Baltimore on the scoreboard in the first inning, when he laced an RBI single to right field, but he was thrown out while trying to stretch it into a double.
Non-roster invitee Aaron Cook, who is trying to win a job in Boston's rotation, pitched two scoreless innings.
Up next for the Orioles: Wei-Yin Chen will make his second start of the spring and look to build off a solid debut against the Twins. The lefty will face Toronto in his first road game during a 1:05 p.m. ET matchup in Dunedin. Armand Galarraga, Pat Neshek, Oliver Drake and Jon Link are also scheduled to pitch for Baltimore.
Brittany Ghiroli is a reporter for MLB.com. Read her blog, Britt's Bird Watch, and follow her on Twitter @britt_ghiroli. This story was not subject to the approval of Major League Baseball or its clubs.