Guthrie even asked for and received permission from Flanagan to wear the number when Flanagan claimed him off waivers in 2007, during his tenure as executive vice president of baseball operations.
"Since the day I was given No. 46, I've had thousands of people tell me that was the number of their favorite pitcher for the Orioles when they were growing up," Guthrie said. "So from Day 1, I think I've been reminded of the legacy and of the work that Mike did not only as a player, but also as a member of the community in Baltimore.
"It's always been special, and now I think it takes on even a new level. He's not going to be forgotten soon, that's for sure."
After thinking about it overnight, Guthrie is considering hanging up his No. 46 for the rest of the season in honor of Flanagan.
Guthrie is looking for input from a number of people, including fans.
"Obviously, there's a lot of emotions flying around right now ... but it's a response that doesn't surprise me from Jeremy," said Orioles manager Buck Showalter. "We'll see. I'm not going to really weigh in on whether [he should do it]. It's a nice gesture."