With Guerrero out, catcher Matt Wieters batted cleanup, while Mark Reynolds and Robert Andino also moved up one spot each to the fifth and sixth spots, respectively.
Jake Fox, who was called up on Tuesday from Triple-A Norfolk, batted seventh as the DH in place of Guerrero. For Fox, it was his first start since May 27.
In six games this year against the Twins, Guerrero is batting .346 with two home runs, five RBIs and two doubles. Guerrero was 3-for-5 on Tuesday night with a double and three runs scored.
After the O's 6-1 win, Guerrero said his wrist -- which was heavily wrapped -- was fine.
Jordan Schelling is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.