Wright didn't have the same velocity on Sunday, and it was clear to Perlozzo that Wright wasn't fully healthy, even after he spent three weeks on the disabled list and made a rehab start at Single-A Frederick.
It's tough to write off a pitcher after just one frustrating start, but this wasn't Wright's first problem with his shoulder. He has had two prior surgeries, and missed half of the 2005 season with a strained shoulder.
Wright went back to Baltimore, and will visit with Dr. Lewis Yocum, who performed his previous surgeries, later this week. His status will be updated further after he meets with Yocum.
"I liked the way he competes, I like the way he is around the guys," Perlozzo said. "It's hard to watch him because he wants to win so bad, and he wants to compete out there. In this case, we want him to get back and get healthy, and hopefully, we'll see him again."
Kurt Birkins was recalled from Triple-A Norfolk to take Wright's roster spot.
If Wright's injury does cause him to miss significant time, Perlozzo said the team will explore all options. Those options could include a trade, though the Orioles will likely wait to see how severe the injury is before that is considered.
With an off-day on Thursday, the Orioles will skip Wright's spot in the rotation, and won't need to replace him until May 8 against the Devil Rays.
It isn't clear who will take Wright's spot in the rotation, but Perlozzo mentioned three players before Monday's game against the Tigers at Comerica Park.
Brian Burres, who pitched four shutout innings in relief of Wright on Sunday, is in consideration. Hayden Penn and Garrett Olson of Triple-A Norfolk are two other possibilities, though Perlozzo said they are long shots.
"I don't think Hayden is healthy enough yet, and Garrett is still a little young and probably needs to pitch a bit more there," Perlozzo said. "I'm sure if he were to go lights-out for a number of starts, he would certainly be an option.
Jamie Walker, who spent five seasons with the Tigers, wasn't sure what type of reception he'd get from the crowd at Comerica Park. It was the first time he had returned to Comerica Park, a season after he was a key reliever out of the Tigers bullpen.
Walker said he would have liked to finish his career in Detroit, but the Orioles made a better financial offer (three years, $12 million) that he couldn't pass up.
"I showed up every day, and I never called in sick. I'm sure there might be some hard feelings, but I had to do what I had to do," Walker said. "The three-year commitment for me was the main thing."
Kevin Millar and Jay Gibbon's statistics may seem backwards, but Perlozzo said they will turn around.
Millar, a righty, is batting .154 against left-handers, while Gibbons, a lefty, is batting .140 against right-handers.
"Those things have a way of evening themselves out as the season goes on," Perlozzo said. "I don't think you can worry about that in 20 some at-bats, you just gotta ride it out and see what happens."
Gibbons is a career .260 hitter against right-handers, while Millar is .282 in his career against left-handers.
Adam Loewen (2-0, 3.20) will get the start against Chad Durbin (1-1, 6.65) in the second of a three-game series at 7:05 p.m. ET on Tuesday at Comerica Park.