"Right now it doesn't look good," Scott said, adding that he will find out the treatment plan on Thursday morning and may have to get an MRI. "I would say probably, [expecting to go on the DL is] what I have been told so far. Any time you deal with a pulled hamstring it's going to be at least two weeks."
Interim manager Juan Samuel also said that Scott will be evaluated on Thursday and "we'll go from there."
After the game, Scott entered the clubhouse on crutches and had to ensure the media he was OK to stand during an interview. He explained that he wasn't sure his ball had cleared the fence, and was hustling around first base when the injury occurred.
"When I hit the ball, I knew I hit it good, but I hit it kind of high. I couldn't tell if it was going to go over," he said. "My thought process coming around first base was the outfielders are both converging and I wanted to make sure if the ball caroms off the wall, I'd be standing at third base.
"So I kind of turned it up as I was getting ready to come around. And when I came around first base it kind of cramped up, my hamstring cramped up and when my leg went forward it pulled."
Television cameras showed Scott carefully walking down the dugout steps with head athletic trainer Richard Bancells. The homer broke a 6-all tie and capped a productive night for Scott, who walked three times and scored three of Baltimore's first seven runs. Jake Fox replaced Scott as the DH and struck out in his only plate appearance in the eighth.
"I am glad the ball went out, but this is frustrating," said Scott, who has hit safely in six of his last seven games. "When I start feeling like this a lot of good things happen. But that's life. You've got to dig down, get on my knees, say my prayers and God will give me the strength to get through it."
If Scott goes to the DL, the Orioles could elect to bring back Felix Pie earlier than planned. Baltimore president of baseball operations Andy MacPhail said prior to Wednesday's game that Pie, who is dealing with an upper back strain, would not be ready to return for this weekend's road series against Boston. The energetic outfielder has been hitting well and playing left field in two rehab games this week with Double-A Bowie, and he told MLB.com before Tuesday's game that he was in no pain and had no trouble throwing.
If the Orioles don't want to rush Pie back, they could opt to call up an emergency outfielder like Triple-A Norfolk's Jeff Salazar, who is hitting .280 with 13 homers and 34 RBIs for the Tides. He was recently named to the International League All-Star Game.
Scott is batting .274. His homer came off of A's reliever Cedrick Bowers and marked the third time the Orioles have gone yard back-to-back this season.
"Hopefully we don't miss him too long," said starter Kevin Millwood, who went five innings in a no-decision on Wednesday. "He's swung the bat really well and been a big part of our offense and hopefully he can get back soon."
Noah Rosenstein is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.