MacPhail said there is no timetable to naming Trembley's heir, although interim coach Juan Samuel will be considered.
"Juan doesn't have to interview, he gets to manage," MacPhail said. "There will be other guys we will talk to and we'll just see how events unfold. We have a pretty good idea going in what our preferences are. But you allow yourself to go through this process so you can be influenced by some of the answers that you get back."
MacPhail said Trembley's dismissal opens the door to start inquiring around baseball about potential candidates. He did not rule out asking other organizations to speak to currently employed coaches, as long as the candidate isn't already a Major League manager.
"To me, the process starts [on Friday]. It doesn't start any earlier than that," MacPhail said. "Then you can get started vetting it, and see where it leads you and see what your appetite is for who is available."
Given that Trembley took a fair amount of criticism for having never played professional baseball, MacPhail was asked if he envisioned the next Orioles manager as someone with Major League managing experience.
"Different managers are going to be real good fits and successful in different environments," he said, using current Dodger skipper Joe Torre and previous Twins manager Tom Kelly as examples. "There are a bunch of Hall of Fame managers that have been terminated in one place or another."
"It is a custom fit, and we need to find the right fit here. We have a lot of young players. If experience is something, that will be that, somebody that's been through showing the way. But often, you're going to talk to a wide spectrum of people, you're going to watch how Juan manages and you're going to be swayed by different things. You have certain predispositions going in, but you might be persuaded otherwise."
Brittany Ghiroli is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.